About BPC-157
BPC-157 is a synthetic pentadecapeptide corresponding to a partial sequence of Body Protection Compound, a protein fragment originally isolated from gastric juice. It is supplied as a lyophilized powder of high analytical purity and is studied in laboratory settings for its activity across several signaling systems associated with tissue integrity, vascular response and cellular stress regulation. Peptsche supplies BPC-157 strictly as a research material for controlled laboratory investigation.
Available Sizes
BPC-157 is supplied as high purity lyophilized powder in multiple vial sizes to support different experimental designs and study durations. All vials are sealed under inert conditions and accompanied by batch specific analytical documentation.
- BPC-157 5 mg Vial
- BPC-157 10 mg Vial
Product Specifications
| Product | BPC-157 (5 mg / 10 mg) lyophilized powder in sealed glass vial |
| Application | Research peptide studied in angiogenesis, cytoprotection and cellular repair models |
| Appearance | Solid white powder |
| Chemical Formula | C62H98N16O22 |
| Molecular Weight | 1419.5 g/mol |
| CAS Number | 137525-51-0 |
| PubChem CID | 9941957 |
| Sequence | Gly Glu Pro Pro Pro Gly Lys Pro Ala Asp Asp Ala Gly Leu Val |
| Synonyms | BPC157, BPC 157, Body Protection Compound 157, Pentadecapeptide BPC-157 |
| Purity | 99% or greater by HPLC, verified per batch |
| Storage | Store sealed at 2 to 8 °C, protected from heat, light and moisture |
| Regulatory Status | Research use compound. Not approved for human or veterinary use. |
What is BPC-157?
BPC-157, also referred to as Body Protection Compound 157, is a stable synthetic peptide composed of fifteen amino acid residues. Its sequence corresponds to a fragment of a larger protein identified in gastric fluid, and the synthetic form is produced to a defined analytical specification for laboratory work rather than isolated from biological material.
Scientific interest in this peptide originated in gastrointestinal research, where investigators examined naturally occurring peptide fragments that appeared to contribute to mucosal integrity under experimental stress conditions. That early work broadened over time into a wider body of preclinical literature examining how the peptide behaves across several distinct model systems.
Published studies to date are overwhelmingly preclinical, comprising in vitro assays and animal models. Controlled human clinical evidence remains limited, and findings across the literature should be interpreted within the boundaries of the experimental systems in which they were produced. BPC-157 is not an approved therapeutic agent in any jurisdiction.
BPC-157 Mechanism of Action (Research Only)
In experimental models BPC-157 demonstrates pleiotropic activity, meaning it has been observed to interact with several signaling systems rather than a single well defined receptor target. This characteristic is one of the principal reasons the compound has attracted sustained research attention.
Structural and Chemical Basis
As a fifteen residue peptide, BPC-157 is short and comparatively stable relative to many larger peptide constructs. Its reported resistance to degradation in aqueous conditions has made it practical to work with in laboratory settings, and this stability profile is frequently cited as a factor in its use as an experimental tool compound.
Nitric Oxide Signaling Modulation
One of the more consistently reported observations across the literature concerns interaction with nitric oxide signaling. Work published in Scientific Reports examined modulatory effects on vasomotor tone and described activation of the Src, Caveolin 1 and endothelial nitric oxide synthase pathway in the models studied. Nitric oxide signaling is broadly implicated in vascular tone regulation and endothelial behaviour, which situates this observation within wider vascular research interest.
Angiogenesis and Vascular Response Pathways
Animal and in vitro studies have examined BPC-157 in connection with angiogenic signaling, the process by which new vascular structures form from existing vessels. A review published in Current Pharmaceutical Design characterised the peptide as angiomodulatory and discussed its relationship to nitric oxide, VEGF and FAK signaling in the models reviewed, alongside vessel formation, edema and thrombogenesis.
Integrated Mechanistic Profile
Taken together, the research literature suggests BPC-157 operates through overlapping mechanisms rather than one isolated pathway. Recurring themes across published work include:
- Modulation of nitric oxide and vascular signaling
- Influence on angiogenic and endothelial responses
- Regulation of cellular stress and inflammatory balance
This breadth is what positions the compound as a versatile research tool for examining tissue integrity across multiple model systems, and equally why mechanistic conclusions drawn from any single study should be treated as provisional.
Note: BPC-157 is supplied strictly for research use only. It is intended as an experimental compound for qualified laboratory personnel and is not a drug, food or cosmetic.
BPC-157 is supplied exclusively for laboratory research use and is not intended for human or veterinary application.
Research Applications (Observations from Studies)
BPC-157 has been examined across a range of preclinical research settings. The following describes areas of published investigation and does not constitute any claim regarding outcomes outside those experimental contexts.
Tissue Organization and Structural Response Models
A substantial portion of the literature involves experimental models evaluating tissue organization and structural response following induced stress. Investigators in this area typically assess markers of cellular migration and matrix organization within defined animal model systems.
Vascular and Microcirculatory Research
Given the recurring nitric oxide and angiogenic findings, the peptide has been studied in connection with vascular signaling and microcirculatory behaviour in non clinical models, including examination of endothelial response and vessel formation dynamics.
Gastrointestinal and Mucosal Research Models
Reflecting its origin as a gastric protein fragment, BPC-157 has been examined extensively in gastrointestinal and mucosal research models. This remains among the most established areas of published investigation for the compound.
Inflammatory Signaling and Cellular Stress Research
Studies have also investigated the peptide in relation to inflammatory signaling pathways and cellular stress response, examining how experimental systems behave under induced stress conditions in the presence of the compound.
BPC-157 is supplied exclusively for laboratory research use and is not intended for human or veterinary application.
BPC-157 Compared With Related Research Compounds
The table below places BPC-157 alongside two related compounds in the Peptsche range. It is offered to clarify differences in classification, molecular target and research context. It should not be read as a comparison of clinical performance, safety, or suitability for any application.
| Characteristic | BPC-157 | TB-500 | Wolverine Blend |
| Research Classification | Synthetic pentadecapeptide | Synthetic acetylated seven residue peptide | Two component co lyophilized research blend |
| Primary Molecular Target | Nitric oxide and angiogenic signaling pathways | Monomeric G actin within the cytoskeleton | Nitric oxide signaling and monomeric G actin, addressed by separate components |
| Mechanistic Profile | Pleiotropic activity across several signaling systems | Actin sequestration and cytoskeletal reorganisation | Two unrelated pathways, combination not studied in published work |
| Primary Research Focus | Tissue integrity, vascular and mucosal models | Cell migration and endothelial models | Vascular and cytoskeletal research in one preparation |
| Structural Design | Fifteen residues, no unnatural residues or modification | Seven residues, N terminal acetyl group, free acid C terminus | Mixture of two peptides, no single formula or CAS number |
| Regulatory Status | Research use compound, not approved for human or veterinary use | Research use compound, not approved for human or veterinary use, and listed by the United States Food and Drug Administration among bulk drug substances withdrawn from consideration for compounding | Research use blend, neither component approved for human or veterinary use, and the TB-500 component appears on the United States Food and Drug Administration list of bulk drug substances withdrawn from consideration for compounding |
BPC-157 is supplied exclusively for laboratory research use and is not intended for human or veterinary application.
Laboratory Handling and Storage Considerations
BPC-157 should be handled in accordance with institutional laboratory procedures and established practice for research peptides. Maintain storage conditions consistent with product documentation, keeping vials sealed and protected from heat, light and moisture. Record lot numbers, storage conditions and preparation methods in laboratory documentation, and retain certificates of analysis alongside study records to support reproducibility.
Laboratory Safety Considerations
BPC-157 should be handled in the same manner as other research compounds without a fully characterised toxicological profile.
- Personal protective equipment: Use appropriate PPE including laboratory coat, nitrile gloves and eye protection.
- Engineering controls: Minimise generation of aerosols or dust. Conduct weighing and transfer procedures using suitable containment.
- Exposure prevention: Avoid inhalation, ingestion and contact with skin or eyes. Do not taste or smell the material. Wash hands thoroughly after handling.
- Storage: Keep containers tightly sealed and protected from light and moisture under the conditions specified.
- Spill response: Address spills using appropriate PPE and institutional spill response procedures. Avoid dry sweeping.
- Disposal: Dispose of unused material, consumables and waste in accordance with local regulations and institutional programmes.
- Documentation: Maintain all lot and handling records. Additional handling guidance is available on request.
Certificate of Analysis and Quality Assurance
Every production lot of BPC-157 supplied by Peptsche undergoes analytical evaluation, and a batch specific Certificate of Analysis accompanies each order to support research documentation, quality control and experimental consistency.
Each Certificate of Analysis typically includes:
- Identity verification using analytical techniques such as mass spectrometry to confirm the molecular characteristics of the material supplied.
- Purity analysis performed by high performance liquid chromatography to quantify purity and identify potential impurities.
- Batch documentation recording lot number, testing date, analytical methods applied and quality assessment results.
- Traceability information to support laboratory recordkeeping and reproducibility across research workflows.
Peptsche works with Janoshik Analytical, an independent testing laboratory, for third party verification of research material quality. Independent testing provides transparency and confidence in product identity, consistency and sourcing, and batch specific documentation can be retained as part of laboratory records and internal quality procedures.
BPC-157 is supplied exclusively for laboratory research use and is not intended for human or veterinary application.
Frequently Asked Questions
What is BPC-157?
BPC-157 is a synthetic pentadecapeptide whose sequence corresponds to a partial sequence of Body Protection Compound, a protein fragment originally isolated from gastric juice. Peptsche supplies it as a lyophilized powder of high analytical purity, sealed in glass vials for controlled laboratory investigation.
What is BPC-157 studied for in research?
Published investigation is preclinical and spans tissue organization and structural response models, vascular and microcirculatory research, gastrointestinal and mucosal research models, and inflammatory signaling and cellular stress research. These describe areas of laboratory study rather than established outcomes outside those experimental contexts.
How does BPC-157 work in laboratory research?
In experimental models BPC-157 demonstrates pleiotropic activity, interacting with several signaling systems rather than a single well defined receptor target. Recurring themes across published work include modulation of nitric oxide and vascular signaling, influence on angiogenic and endothelial responses, and regulation of cellular stress and inflammatory balance.
How is the quality of Peptsche BPC-157 verified?
Every production lot of Peptsche BPC-157 is evaluated analytically, with identity confirmed using techniques such as mass spectrometry and purity quantified by high performance liquid chromatography. Peptsche works with Janoshik Analytical, an independent testing laboratory, for third party verification, and a batch specific Certificate of Analysis accompanies each order.
How should unopened BPC-157 be stored?
Unopened vials should be stored sealed at 2 to 8 °C, protected from heat, light and moisture. Vials should reach ambient temperature before opening, and lot number, storage conditions and preparation date should be recorded in laboratory documentation so results stay traceable to a batch.
Is BPC-157 intended for human use?
No. BPC-157 is supplied strictly for laboratory research use only. It is not approved for human consumption, veterinary use, diagnosis, treatment or any medical application.
Why do researchers choose Peptsche for BPC-157?
Peptsche supplies BPC-157 at 99% or greater purity by HPLC, verified per batch, sealed under inert conditions with batch specific analytical documentation. Independent third party verification and full lot traceability support reproducibility across research workflows.
Scientific References
- Seiwerth S, Brcic L, Vuletic LB, Kolenc D, Aralica G, Misic M, Zenko A, Drmic D, Rucman R, Sikiric P. BPC 157 and blood vessels. Current Pharmaceutical Design. 2014;20(7):1121 to 1125. https://pubmed.ncbi.nlm.nih.gov/23782145/
- Hsieh MJ et al. Modulatory effects of BPC 157 on vasomotor tone and the activation of Src Caveolin 1 endothelial nitric oxide synthase pathway. Scientific Reports. 2020. https://www.nature.com/articles/s41598-020-74022-y
- Józwiak M et al. Multifunctionality and Possible Medical Application of the BPC 157 Peptide. Literature and Patent Review. Pharmaceuticals. 2025;18:185. https://www.mdpi.com/1424-8247/18/2/185
RESEARCH USE ONLY
These compounds are NOT intended for human consumption, clinical use, or veterinary applications. We are not affiliated with any pharmaceutical companies or their commercial medications. By placing an order, you certify these materials will be used exclusively for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.